The 463rd Hospital： Gamma Knife Center

I. Basic information

In 2003, No.463 Hospital of China People’s Liberation Army introduced the latest international body (whole body) OPEN gamma knife and MASEP-SRRS head gamma knife. The hospital is equipped with advanced 64-slice spiral CT, 1.5T nuclear magnetic resonance positioning system, dedicated network transmission, TPS treatment planning system and GMP standard cell biological detection and treatment laboratory. A research center for non-invasive treatment of tumors has been established, which is also the largest gamma knife treatment center in Northeast China so far. There are 50 beds in the ward, and more than 150 cases are treated every month. With advanced equipment, excellent technology and rich experience, the center can treat a variety of intracranial and systemic benign and malignant tumors, as well as cerebral arteriovenous malformation (AVM), trigeminal neuralgia, epilepsy and other diseases without surgery, bleeding, trauma and changing the basic shape of the human body. Especially for brain stem tumors, brain metastases, glioma, germ cell tumors, pituitary tumors, meningiomas, AVM, nasopharyngeal tumors, lung tumors, liver tumors, esophageal tumors, pancreatic tumors, lymph node metastases, etc., it has a good analgesic effect on cancer pain. And it is not limited by diabetes, hypertension, heart disease and other coexisting diseases. More than 10,000 cases have been treated, and the total effective rate is over 90%. Liaoning TV Station, Shenyang TV Station, shenyang evening news, Shenyang People’s Broadcasting and Television Station and other media have repeatedly reported that gamma knife, an "invisible knife", has achieved the purpose of alleviating pain, prolonging life, and "patients suffer less and their families suffer less". It has brought happiness to thousands of families, and with the increase of treatment times, it will certainly bring joy to more families!

The purpose of the center: to relieve pain, prolong life and enjoy a healthy life for patients with high-quality services, technologies and equipment.

Second, talent construction

(1) Staffing

There are 30 medical staff in the center, including 10 doctors, 6 technicians, 2 physicists and 12 nurses. There are 4 senior titles, 5 intermediate titles and 3 graduate students.

(2) Academic leaders

Li Chuntian, male, born in 1964, graduated from the Fourth Military Medical University with a master’s degree in medicine, chief physician and professor of Liaoning Medical College. He began to engage in radiotherapy in 2004 and is currently the director of the center. Academic posts: He is currently a member of the Precision Radiotherapy Technical Committee of China Biomedical Engineering Society, a special expert of China Anti-Cancer Association, a member of the Tumor Radiotherapy Professional Committee of the whole army, a deputy director of the Radiotherapy Committee of shenyang military area command, a standing director of the Radiotherapy Professional Committee of Liaoning Cell Society, a standing director of the Stem Cell and Regeneration Professional Committee of Liaoning Cell Society, a member of the Radiotherapy Professional Committee of Liaoning Medical Association, a member of Liaoning Anti-Cancer Association and a member of the expert database of Liaoning and Shenyang Medical Accident Appraisal Committees.

He has been a doctor for 30 years and has rich clinical experience. He is especially good at gamma-ray stereotactic radiotherapy for head and neck tumors (lesions), lung cancer, esophageal cancer, liver cancer, pancreatic cancer, mediastinal tumors and head and neck tumors. He also has in-depth research on molecular targeted therapy, biotherapy and individualized precision medicine for malignant tumors, and has treated more than 10,000 cases of systemic tumors. He has won the third-class merit twice, won four awards for scientific and technological progress and medical achievements of the whole army, edited/edited 15 medical monographs and published more than 50 academic papers.

(three) the main technical backbone

Yin Zeng, male, born in 1961, deputy chief physician. Graduated from the Fourth Military Medical University with a master’s degree. After graduation, he has been engaged in neurosurgery, and began to engage in radiotherapy in 2004, mainly responsible for gamma knife treatment of the head, such as the diagnosis and treatment of intracranial benign and malignant tumors, cerebral arteriovenous malformation (AVM), trigeminal neuralgia, epilepsy and other diseases. He is especially good at stereotactic radiosurgery for brain stem tumors, brain metastases, gliomas, germ cell tumors, pituitary tumors, meningiomas and AVM. He is currently a member of the Standing Committee of the Stem Cell and Regeneration Committee of Liaoning Cytology Society and a member of the expert database of Liaoning and Shenyang Medical Accident Appraisal Committees.

Third, medical care work

(1) Medical work

The center pays attention to the implementation of various rules and regulations, strengthens business study, insists on collective consultation of cases, organizes discussion on difficult cases irregularly, and regularly solicits opinions from patients and their families. The satisfaction of patients and their families is the gold standard to measure the quality of medical care, and the satisfaction rate of hospital spot checks is high. Insist on giving publicity lectures on cancer prevention and treatment for patients and their families every Thursday, and achieve good results. In order to meet the treatment needs of patients, the medical staff in the center always work overtime and often work late into the night. The number of patients treated has steadily increased. In the past 10 years, the center has treated more than 15,000 patients, and no medical errors and accidents have occurred. In Northeast China, the number of monthly treatment in our center is still in the lead. Actively participate in health knowledge lectures of Liaoning and Shenyang TV stations, and publicize and report typical cases in newspapers and periodicals for many times to improve the visibility of the center.

(2) Nursing work

Pay attention to smiling, warm and humanized service, and insist on providing two lunches for each patient treated with gamma knife for the head. The names of the department director, head nurse, attending doctor and responsible nurse are publicized by cards at the bedside of the hospital, and a warm reminder board is set up to make the patients feel as warm and feel as if they are at home as soon as they are admitted to the hospital.

(3) Serving the soldiers

The center strictly abides by the hospital’s "Ten Commitments" to serve the army, and is personally treated by personnel with the title of deputy chief physician or above. Since its establishment, it has treated 103 military patients and their families, and achieved satisfactory results, which has been well received by military leaders and patients.

Fourth, technical characteristics

(A) expertise

1. 63 cases of early laryngeal carcinoma were treated by gamma knife. Gamma knife therapy for early laryngeal cancer was first carried out in No.463 Hospital of PLA. Compared with surgery, it can preserve the pronunciation function and greatly improve the quality of life of patients.

2. 280 cases of brain stem tumors were treated with gamma knife. Brain stem tumor is a "forbidden area" in neurosurgery, and gamma knife therapy is an ideal treatment method. Through continuous exploration, the individualized treatment effect is satisfactory, which not only cures the disease, but also ensures safety.

3. 99 cases of massive hepatocellular carcinoma were treated by gamma knife in different target areas. In view of massive liver cancer, the dose distribution is more uniform and patients are more tolerant according to the gamma knife treatment method of dividing the target area by general radiation strip.

4. Multi-target gamma knife therapy for lung metastatic carcinoma was performed in 195 cases. After optimization and integration and simultaneous treatment of multiple target areas, the radiation damage of normal lung tissue was not significantly increased by observation.

5. Multidisciplinary cooperation in tumor.

(1) In collaboration with the Cell Therapy Center of Hematology Department, targeted immune technology (ACTL technology) based on dendritic cells infected by recombinant adeno-associated virus was carried out to treat malignant tumors. Biological therapy (CIK, DC-CIK, ACTL) formed a certain scale and had certain influence in this area;

(2) Make full use of the platform of multidisciplinary cancer consultation center;

(3) Keep close contact with experts from PLA, Air Force and Navy General Hospital and Fudan University Cancer Hospital for remote consultation;

(4) Individual gene detection of tumor and selection of the best treatment plan.

(2) New technologies and new businesses

1. Tumor biotherapy (CIK, DC-CIK, ACTL);

2. Molecular targeted therapy for tumor;

3. Individualized gene therapy based on DNA sequencing of tumor cells.

V direction of scientific research

(1) Gamma knife dosimetry study of multiple metastatic lung cancer.

Gamma knife treatment planning system can set up six target areas at most at a time. By optimizing the combination, the adjacent lesions are set as one target area, which can treat more than ten or more lesions at the same time, greatly shortening the course of treatment.

(2) Dosimetric study of brain stem tumors

The brain stem requires a very strict dose, especially the medulla oblongata, so it is necessary to strictly control the dose and formulate an individualized treatment plan.

(3) Dosimetric study of pancreatic cancer

Pancreatic cancer has a high degree of malignancy and requires a high dose, but sensitive tissues and organs such as duodenum should also be taken into account. The dose around the lesion should not be less than 48Gy and should be carefully designed.

(4) ACTL immune targeted therapy for glioma.

Sixth, the discipline orientation

There are more than 180 gamma knife centers in China, and the number of cases treated is in the top 10. Compared with similar disciplines in the military, this discipline has certain advantages in medical treatment, and it is in the lead compared with similar disciplines in the military region, but the gap in academic papers and scientific research is obvious.