The Central Network Information Office launched a one-month special campaign to prevent the "rice circle" problem from spilling over to sports, e-sports and other fields.

  On January 18th, the Central Network Information Office reported that in order to create a festive and peaceful online public opinion atmosphere for the Spring Festival, the Central Network Information Office decided to launch a one-month special campaign of "Renovating the network environment for the Spring Festival in 2023" from now on. The special action will be carried out from now until the end of February.

  According to reports, this special action specifically rectified the following six aspects:

  Continue to consolidate the achievements of "rice circle" governance,

  Effectively maintain a good network entertainment ecology.

  First, pay close attention to the situation of the Spring Festival Gala and the Spring Festival film and television works, rectify and take the opportunity to provoke the fans to tear each other and attack each other, and prevent the problem of "rice circle" from spilling over to other fields such as sports and e-sports. The second is to strengthen the standardized management of online information of entertainment stars during the Spring Festival to prevent information such as gossip and privacy disclosure from occupying public platform resources. Third, it is strictly forbidden for the website platform to set up a new list selection for individual stars through the Spring Festival activities, and it is not allowed to induce support in disguise. Fourth, focus on rectifying all kinds of bad "online celebrity" problems, seriously deal with "online celebrity" bloggers who have problems such as speculating on bad behavior history and deliberately pretending to be ugly, and investigate and deal with the so-called "inspirational online celebrity" who shows off his prison experience and beautifies his life.

  Strictly investigate the network to show off wealth and promote overeating.

  And other issues, to avoid the rebound of bad atmosphere.

  First, focus on cleaning up the graphic and video information that deliberately shows off luxury life by means of "sky-high New Year’s Eve", "sky-high year-end bonus", "waterfall lucky money", "top luxury house" and "sky-high bride price", and do not maliciously speculate on issues such as invisible showing off wealth and deliberately comparing. The second is to investigate and deal with the deliberate display of overeating and eating pictures during the Spring Festival, and to promote extravagant and wasteful information.

  Focus on investigating and organizing illegal behaviors such as online gambling and online fraud.

  First, continue to clean up gambling information, resolutely shut down illegal website platforms that organize gambling transactions during the Spring Festival, and seriously investigate and deal with online gambling in the name of chess games, treasure-winning games, or by using functions such as building red envelopes. Second, the problem of online fraud in the name of "Spring Festival travel rush Red Packet Subsidy", "Spring Festival Blessing Collection" and "Paid Transfer of Fuka" will be strictly rectified, and the activities such as "Red Packet Rain" and "bonus hunter" will be strictly prevented from tricking users into swiping their bills.

  Increase feudal superstition and

  Efforts to rectify bad phenomena

  First, we will continue to clean up posts and video information that advocate speculation on feudal superstitions and bad habits, and deal with problems such as providing fortune-telling and divination illegal services. The second is to strictly control the problem of creating various vulgar people such as "hotel garden", "scenic garden", "snow garden" and "takeaway garden" by means of vulgar dress and explicit movements, and to carry out speculation and drainage.

  Strictly control cyber bullying, internet addiction and other issues, and increase the protection of minors.

  First, focus on cleaning up video content that bullies and spoofs minors, or induces them to engage in dangerous actions, and continue to rectify and use "online celebrity children" for profit. The second is to strictly control the use of children’s smart devices, online games, live games and other channels to spread pornographic and vulgar, bloody and violent information to minors. The third is to focus on rectifying illegal renting and buying numbers, encourage parents to take the initiative to set up a youth model for minors, and prevent minors, especially left-behind children in rural areas, from indulging in the Internet.

  Thoroughly rectify false information and other issues,

  Prevent rendering gloomy emotions

  First, focus on rectifying rumors and rumors related to the economy and people’s livelihood, food hygiene, safety accidents and other fields during the Spring Festival, increase the rumor of sudden rumors, and clarify the facts in time. Second, we will continue to intensify efforts to rectify network rumors related to epidemic diseases, investigate and deal with such problems as fabricating the epidemic trend of the Spring Festival, fabricating the latest epidemic prevention policy, forging anti-virus secret recipes, and fabricating patient experiences, so as to prevent misleading the public and causing social panic. The third is to strictly investigate and deal with false plots such as year-end debt collection, bankruptcy, crying and selling miserable, and to trick netizens into rewarding consumption by deducing vulgar plots such as emotional disputes and family ethics. Fourth, strictly control issues such as deliberately inciting regional attacks, spreading anxiety, and rendering the dark side of society by publishing false information such as returning home notes and returning home.

  Text/reporter Qu Chang Intern Li Wanling

The Blade of the Ghost Extinction, which topped the film history and was "completely concentrated" and broke the circle.

Time writer | picking up fools

Read it and don’t agree to turn on the youth mode.

A new historical record was born!

On December 28, 2020, the official Express reported that after 73 days of its high-profile release, it won a total box office of 32.47 billion yen.

Successfully surpassed Spirited Away’s 31.68 billion yen and topped the Japanese box office list.

Or you can say that it finally broke the box office record of the latter in Japanese film history for 18 years and became the most popular cinema film in Japanese history.

The "victory or defeat" is known and the dust settles.

This result is reasonable for the people who have been obsessed with betting on "who is the first" for two months, and it is not surprising.

Time Jun specially invited a person in Japan who has finished painting the theatrical version of "Ghost Destroying @ Picking up Fools".

Before the screening date in the mainland has yet to be determined, I will be greedy again for hundreds of millions of times-

For most Japanese audiences, it may be hard to imagine the popularity of this animated film in China due to the introduction of the film and the lag of market information.

Take TOHOシネマズ in Shinjuku, Tokyo as an example. Even though it has been shown for 73 days, on December 28th, Blade of the Ghost: Infinite Train (hereinafter referred to as Infinite Train).

Comparing Doraemon: Walk with Me 2, which was released in the same period, and Wonder Woman 1984, a new interpretation of the Three Kingdoms, the statistical data of the three can barely reach half of the relevant data of Infinite Train.

What’s more,.

Whether it is joked by netizens or quoted by the new Prime Minister Suga Yoshihide in the parliamentary defense (one of the "killing skills" used by the leading role Tanjiro) as a golden sentence of active atmosphere.

Even a group of people who refused to "surrender" to Blade of the Ghost, spontaneously posted tags on SNS and sent them to Twitter for hot search (Japanese original is "キメハラ": キメ is the abbreviation of Blade of the Ghost, ハラ)

Even Kitano Takeshi joined the ghost-destroying cos army.

But interestingly, it is different from the first season of animation launched by Blade of the Ghost in 2019.

With the "long standby" of the release time of "Infinite Train", the evaluation of the film itself seems to begin to show a mixed trend after the initial wave of "gods" praise.

Views such as "slow fever", "wordiness", "sensational embarrassment" and "memory killing by people" and so on also represent another kind of "deviation from the mainstream" voice.

In view of the fact that the film has not been released in the mainland and a well-known basic truth-"there are a thousand Hamlets in the eyes of a thousand people".

Let’s put aside the movie spoilers that affect the perception (in case of being scolded) and the business angle involving brand marketing (knowledge blind area).

The film begins at the end of the first season of animation. Tell the story of the protagonist Tanjiro Zaomen who joined the Ghost Killing Team, and after completing his studies in Butterfly House, he went to purgatory with Xing Shoulang, the predecessor of the Ghost Killing Team, known as "Yanzhu", and took the Infinite Train to perform the task.

According to the plot development of the original comic book,

As far as the story itself is concerned, at first glance, Blade of the Ghost does not seem to be divorced from the traditional structure and classic elements of the Jump system.

If that’s all, Blade of the Ghost Extinguishes has a leading list of "Dead Sea of Fire" (Death, Naruto and One Piece, which were once recognized as the most popular "three major migrant workers"), and then "Steel Refining" and "Giant" are the world’s first battles, and it can still spread from a hundred schools of thought to deus ex and become an annual explosion.

Probably it has to be classified as some kind of "secondary metaphysical event" that seeks benevolence and is merciful to God.

However, it is obvious that Blade of the Ghost and its theatrical version of Infinite Train have continued their high popularity since their broadcast and release.

Among the many interpretations of "ghost extinction becomes popular", some key words are repeatedly mentioned, such as "subtraction of content"; "delicate emotional expression"; "ufotable’s Conscience Making" and "OP’s Blessing of Red Lotus"; As well as the hot connection between animation and film, it may all be regarded as the reason why Blade of the Ghost Out stands out.

However, when we put aside the open-ended framework analysis, we try to cut in from a more "content" perspective.

Other viewpoints, for example, seem to be closer to the unique core of the "Ghost Extinction" story.

Many times, when we talk about "good and evil", we often acquiesce that the two have the natural attribute of just opposition.

People who are heinous will be ruthlessly strangled by those who hate evil, and everything seems to be a matter of course, and there is nothing to explore.

When the above context is put into the "ghost-out" world where people and ghosts coexist, the settings that the audience can quickly accept without thinking must include the natural confrontation between good and evil:

.

This seems to be all the reasons why the protagonist and villain exist and the story can be unfolded. Is that really all?

The little boss in TV animation was also "freed" after being knocked down by Tanjiro.

Simply and rudely accepting the background of the story will often lead us to ignore some contents hidden in the background that the author wants to express.

My teacher Hu Shiqing created a "mediocre" man who violated the convention-

From this, we noticed that the hero Tanjiro, who entered the ghost killing team, did not hesitate to give "unnecessary care" to every evil ghost in actual combat.

Tanjiro’s pity for the enemy "ghost" is his greatest charm.

In this process, we have seen writers who have never been recognized and misunderstood their parents’ love. They were not born as ghosts, but also had human experiences before, and all kinds of torture and unfair fate were embarrassing.

However, good and evil, that is, people and ghosts in the works, have always been two sides of one body.

As for our "ordinary" protagonist Tanjiro, he did not choose a long-winded "oral escape" education in the ghost killing action. He crusaded against evil spirits to protect life and tolerated the dead souls to understand life.

From this point of view, the position represented by Tan Zhilang is neither a ghost killing team from the perspective of "subject" nor an evil ghost defined as the concept of "the other".

Instead, he jumped out of the dualistic structure of good and evil and returned to the starting point and root of why people are (or used to be).

Similar plot arrangements can be seen everywhere in Blade of the Ghost and its theatrical films.

If it is necessary to go up in value, such an arrangement can not only reflect the humanism of "subject philosophy", but also "those who are more expensive than gentlemen can be inclusive, so that those who are intelligent can have their own views, while those who are stupid can be self-sufficient".

There is also no lack of reflection on the current situation of public opinion in the Internet ecology, which mostly replaces the confrontation of views with strangulation of positions.

Back to Infinite Train.

I watched this film twice before and after in the Japanese cinema, and to be honest, I felt completely different twice.

As early as before the film was released, all kinds of "ghost extinction" announcements and commodity linkage had been overwhelming, and the excellent performance of CG production tycoon "UFO Club" in the first season of animation made me look forward to the theatrical version of "Train".

However, a "but" that I’m afraid no one wants to see-

Some people say that "Infinite Train" is "unworthy of virtue" and "it is really difficult to be inferior under the fame", but such a harsh evaluation is not necessary.

As far as I am concerned,

There is nothing wrong with it, but it is not exquisite enough.

I have seen the burning will of fire, the courage to put all your eggs in one basket for what you want to protect, the gentle and firm strong, the flesh and blood human beings (I have also seen the visual picture of being tempted back and forth on the edge of the "dark curtain").

However, in the 117-minute film, there are always some vivid clips, just like the bilibili barrage, which reminds you that "you can start crying here".

At least in my slightly unreasonable demands, I may be able to shape the image and pave the way for the background of Xing Shoulang, the protagonist of this film, "Yan Zhu".

The cartoonist Wu Yi Hu Shiqing gave himself a self-portrait of a crocodile with glasses.

In order to express their strong desire for survival, it is still necessary to emphasize that the above views are very subjective, and different people have different opinions.

Subsequently, "Infinite Train" not only opened paintings all over Japan, but also entered the cinemas of China, Hong Kong and Taiwan.

Its good box office and high popularity need not be repeated.

.

I can’t say that I haven’t been influenced by outside opinions. After being swept by the increasingly fierce "ghost-killing whirlwind" for two months, I finally decided to go into the cinema again, put aside my preconceived impression and watch the "infinite train" again.

The ticket stub (and special edition) is here

Facing the story of these teenagers for the second time, I no longer care about the so-called "literary drama" and "rhythm", but try to put myself on the screen and bring it into the first perspective of the leading group.

This time, it was really easy to cry, and there was no sensational trap of crying in the hope that the audience would cry.

After the show, I couldn’t help asking the middle school students who started sobbing in the middle of the film next door. I was just curious, because the plot was still a comedy with expressions flying all over the place.

His answer accidentally poked me in the heart:

After the Blade of Ghost Destroyed continuously dominated the major sales charts, it was inevitably compared with the closely followed One Piece, the "Top Stream" predecessor "The Attack Giant", and even the bloody memory of the previous generation "saint seiya the Saint" and the recognized masterpiece "The Alchemist of Steel" which was also written by female cartoonists, and so on.

Summed up, it can probably be written as an excellent graduation thesis of ACG major.

But in any case, it must be admitted that when creating a "ghost-destroyed world", my teacher Hu Shiqing did not choose to take the old road of Jump.

Put the story development and character growth in a grand and complicated pattern, and discuss the fate of life and death, the end of ethnic politics and scientific and technological development, or the beginning of reshaping civilization like serious literature.

It doesn’t even have any brain-burning design of intrigue and infighting.

Similarly, the theatrical version of Infinite Train continues this feature well.

During the two-hour viewing,

Even in some ketchup pictures of PG12, what the work itself wants to convey can still be accurately grasped.

This may be another kind of warm-blooded feeling that directly hits people’s hearts besides the grand narrative of human destruction and religious philosophy.

Of course, if the above subjective views still can’t make you agree.

Then, at least in the film soundtrack, especially the tear killer and inflammation, I believe everyone can reach a consensus.

Whether it’s Sign, where the leaves of wood are flying, the fire is endless, or Fantasy of Tianma, where human beings can be very gentle and strong for love.

If you are very familiar with them, then the end of the next second grade may not seem too embarrassing.

Finally, I called the production team from a distance. Now that the theatrical version of the film has won the top spot, can we hurry up the trouble in the second season?

The 463rd Hospital: Gamma Knife Center

I. Basic information

In 2003, No.463 Hospital of China People’s Liberation Army introduced the latest international body (whole body) OPEN gamma knife and MASEP-SRRS head gamma knife. The hospital is equipped with advanced 64-slice spiral CT, 1.5T nuclear magnetic resonance positioning system, dedicated network transmission, TPS treatment planning system and GMP standard cell biological detection and treatment laboratory. A research center for non-invasive treatment of tumors has been established, which is also the largest gamma knife treatment center in Northeast China so far. There are 50 beds in the ward, and more than 150 cases are treated every month. With advanced equipment, excellent technology and rich experience, the center can treat a variety of intracranial and systemic benign and malignant tumors, as well as cerebral arteriovenous malformation (AVM), trigeminal neuralgia, epilepsy and other diseases without surgery, bleeding, trauma and changing the basic shape of the human body. Especially for brain stem tumors, brain metastases, glioma, germ cell tumors, pituitary tumors, meningiomas, AVM, nasopharyngeal tumors, lung tumors, liver tumors, esophageal tumors, pancreatic tumors, lymph node metastases, etc., it has a good analgesic effect on cancer pain. And it is not limited by diabetes, hypertension, heart disease and other coexisting diseases. More than 10,000 cases have been treated, and the total effective rate is over 90%. Liaoning TV Station, Shenyang TV Station, shenyang evening news, Shenyang People’s Broadcasting and Television Station and other media have repeatedly reported that gamma knife, an "invisible knife", has achieved the purpose of alleviating pain, prolonging life, and "patients suffer less and their families suffer less". It has brought happiness to thousands of families, and with the increase of treatment times, it will certainly bring joy to more families!

The purpose of the center: to relieve pain, prolong life and enjoy a healthy life for patients with high-quality services, technologies and equipment.

Second, talent construction

(1) Staffing

There are 30 medical staff in the center, including 10 doctors, 6 technicians, 2 physicists and 12 nurses. There are 4 senior titles, 5 intermediate titles and 3 graduate students.

(2) Academic leaders

Li Chuntian, male, born in 1964, graduated from the Fourth Military Medical University with a master’s degree in medicine, chief physician and professor of Liaoning Medical College. He began to engage in radiotherapy in 2004 and is currently the director of the center. Academic posts: He is currently a member of the Precision Radiotherapy Technical Committee of China Biomedical Engineering Society, a special expert of China Anti-Cancer Association, a member of the Tumor Radiotherapy Professional Committee of the whole army, a deputy director of the Radiotherapy Committee of shenyang military area command, a standing director of the Radiotherapy Professional Committee of Liaoning Cell Society, a standing director of the Stem Cell and Regeneration Professional Committee of Liaoning Cell Society, a member of the Radiotherapy Professional Committee of Liaoning Medical Association, a member of Liaoning Anti-Cancer Association and a member of the expert database of Liaoning and Shenyang Medical Accident Appraisal Committees.

He has been a doctor for 30 years and has rich clinical experience. He is especially good at gamma-ray stereotactic radiotherapy for head and neck tumors (lesions), lung cancer, esophageal cancer, liver cancer, pancreatic cancer, mediastinal tumors and head and neck tumors. He also has in-depth research on molecular targeted therapy, biotherapy and individualized precision medicine for malignant tumors, and has treated more than 10,000 cases of systemic tumors. He has won the third-class merit twice, won four awards for scientific and technological progress and medical achievements of the whole army, edited/edited 15 medical monographs and published more than 50 academic papers.

(three) the main technical backbone

Yin Zeng, male, born in 1961, deputy chief physician. Graduated from the Fourth Military Medical University with a master’s degree. After graduation, he has been engaged in neurosurgery, and began to engage in radiotherapy in 2004, mainly responsible for gamma knife treatment of the head, such as the diagnosis and treatment of intracranial benign and malignant tumors, cerebral arteriovenous malformation (AVM), trigeminal neuralgia, epilepsy and other diseases. He is especially good at stereotactic radiosurgery for brain stem tumors, brain metastases, gliomas, germ cell tumors, pituitary tumors, meningiomas and AVM. He is currently a member of the Standing Committee of the Stem Cell and Regeneration Committee of Liaoning Cytology Society and a member of the expert database of Liaoning and Shenyang Medical Accident Appraisal Committees.

Third, medical care work

(1) Medical work

The center pays attention to the implementation of various rules and regulations, strengthens business study, insists on collective consultation of cases, organizes discussion on difficult cases irregularly, and regularly solicits opinions from patients and their families. The satisfaction of patients and their families is the gold standard to measure the quality of medical care, and the satisfaction rate of hospital spot checks is high. Insist on giving publicity lectures on cancer prevention and treatment for patients and their families every Thursday, and achieve good results. In order to meet the treatment needs of patients, the medical staff in the center always work overtime and often work late into the night. The number of patients treated has steadily increased. In the past 10 years, the center has treated more than 15,000 patients, and no medical errors and accidents have occurred. In Northeast China, the number of monthly treatment in our center is still in the lead. Actively participate in health knowledge lectures of Liaoning and Shenyang TV stations, and publicize and report typical cases in newspapers and periodicals for many times to improve the visibility of the center.

(2) Nursing work

Pay attention to smiling, warm and humanized service, and insist on providing two lunches for each patient treated with gamma knife for the head. The names of the department director, head nurse, attending doctor and responsible nurse are publicized by cards at the bedside of the hospital, and a warm reminder board is set up to make the patients feel as warm and feel as if they are at home as soon as they are admitted to the hospital.

(3) Serving the soldiers

The center strictly abides by the hospital’s "Ten Commitments" to serve the army, and is personally treated by personnel with the title of deputy chief physician or above. Since its establishment, it has treated 103 military patients and their families, and achieved satisfactory results, which has been well received by military leaders and patients.

Fourth, technical characteristics

(A) expertise

1. 63 cases of early laryngeal carcinoma were treated by gamma knife. Gamma knife therapy for early laryngeal cancer was first carried out in No.463 Hospital of PLA. Compared with surgery, it can preserve the pronunciation function and greatly improve the quality of life of patients.

2. 280 cases of brain stem tumors were treated with gamma knife. Brain stem tumor is a "forbidden area" in neurosurgery, and gamma knife therapy is an ideal treatment method. Through continuous exploration, the individualized treatment effect is satisfactory, which not only cures the disease, but also ensures safety.

3. 99 cases of massive hepatocellular carcinoma were treated by gamma knife in different target areas. In view of massive liver cancer, the dose distribution is more uniform and patients are more tolerant according to the gamma knife treatment method of dividing the target area by general radiation strip.

4. Multi-target gamma knife therapy for lung metastatic carcinoma was performed in 195 cases. After optimization and integration and simultaneous treatment of multiple target areas, the radiation damage of normal lung tissue was not significantly increased by observation.

5. Multidisciplinary cooperation in tumor.

(1) In collaboration with the Cell Therapy Center of Hematology Department, targeted immune technology (ACTL technology) based on dendritic cells infected by recombinant adeno-associated virus was carried out to treat malignant tumors. Biological therapy (CIK, DC-CIK, ACTL) formed a certain scale and had certain influence in this area;

(2) Make full use of the platform of multidisciplinary cancer consultation center;

(3) Keep close contact with experts from PLA, Air Force and Navy General Hospital and Fudan University Cancer Hospital for remote consultation;

(4) Individual gene detection of tumor and selection of the best treatment plan.

(2) New technologies and new businesses

1. Tumor biotherapy (CIK, DC-CIK, ACTL);

2. Molecular targeted therapy for tumor;

3. Individualized gene therapy based on DNA sequencing of tumor cells.

V direction of scientific research

(1) Gamma knife dosimetry study of multiple metastatic lung cancer.

Gamma knife treatment planning system can set up six target areas at most at a time. By optimizing the combination, the adjacent lesions are set as one target area, which can treat more than ten or more lesions at the same time, greatly shortening the course of treatment.

(2) Dosimetric study of brain stem tumors

The brain stem requires a very strict dose, especially the medulla oblongata, so it is necessary to strictly control the dose and formulate an individualized treatment plan.

(3) Dosimetric study of pancreatic cancer

Pancreatic cancer has a high degree of malignancy and requires a high dose, but sensitive tissues and organs such as duodenum should also be taken into account. The dose around the lesion should not be less than 48Gy and should be carefully designed.

(4) ACTL immune targeted therapy for glioma.

Sixth, the discipline orientation

There are more than 180 gamma knife centers in China, and the number of cases treated is in the top 10. Compared with similar disciplines in the military, this discipline has certain advantages in medical treatment, and it is in the lead compared with similar disciplines in the military region, but the gap in academic papers and scientific research is obvious.

The 2023 Euler Good Cat/Good Cat GT Mulan Edition is sold for 149,800 yuan, with a limited time discount of 20,000 yuan.

  [Pacific Auto New Car Channel] On August 20th, the 2023 Euler Good Cat (parameter picture) (inquiry base price | reference matching)/Good Cat GT Mulan Edition was officially launched, and three models were launched, with the price range of 14.98-165,800 yuan. It is worth mentioning that the official launch of time-limited cash benefits 20,000 yuan, namelyThe limited-time price range is 12.98-14.58.Ten thousand yuan. If you have been paying attention to the pure electric household scooter in the range of 100,000-150,000 yuan recently, you can pay attention to the Euler Good Cat/Good Cat GT model listed this time, especially for female friends. Next, I will give you an analysis of the characteristics of this model and related car purchase suggestions.

2023 Euler Good Cat/Good Cat GT Mulan Edition Honorable Guide Price Model Price (ten thousand yuan) 2023 401km Standard Endurance Honorable Model 14.98 (limited time 12.98)2023 500km Long Endurance Honorable Model 16.58 (limited time 14.58)2023 Mulan Edition 401km Honorable Model 15.38 (limited time 13.38) Note

Car purchase rights:

  If you have already learned about it before and are ready to make a decision, you can focus on the rights and interests of car purchase:

  In terms of car purchase rights, in addition to the official limited-time cash benefit of 20,000 yuan mentioned at the beginning of the article, the good cat honor type enjoys the V2L external discharge function worth 2,999 yuan for free, which is quite practical for camping in the wild. In addition, the good cat GT intelligent driver-assisted optional package enjoys a 50% discount, which is still attractive to friends who like the driver-assisted function.

  If you still don’t know about this car, or don’t know its advantages and disadvantages, then look down.

About Euler’s good cat, you must understand the changes and highlights

  The 2023 Euler Good Cat and the 2023 Euler Good Cat GT (inquiry price | check and match) Mulan version are already on sale. Let’s briefly review the basic information of this model.

  First of all, Euler Good Cat Positioning is a small pure electric car with a length, width and height of 4235x1825x1596mm and a wheelbase of 2650mm. The overall size is similar to that of the popular dolphins sold at this level. In terms of battery life, it is equipped with lithium iron phosphate battery, and CLTC pure battery life is available in 401km and 501km versions, both of which are equipped with fast charging. In terms of power, they are all equipped with 105kW front motors.

  The Good Cat GT Mulan Edition only provides a 401km version, and the motor power is even higher, reaching 126kW. The official acceleration of 0-100km/h reaches 6.9 seconds, which is quite excellent in the same level.

  In terms of design, Euler Good Cat is round and lovely, but also with a little retro style, which is more distinctive in the same class of models and relatively more pleasing to female users. I believe that after reading the pictures, you have your own conclusions.

  In terms of interior, it is exquisite style, the overall design is relatively simple, and the interior design with double colors is adopted, so the whole cockpit is still lively and young. In terms of configuration, it is regarded as the mainstream level in the same price model, such as dual screen, and the mainstream voice and entertainment functions are equipped. In terms of space, it is quite satisfactory in the same level, and the city is fully competent for transportation.

  The Good Cat GT Mulan Edition is mainly adjusted in appearance and interior design. For example, details such as wheel hub, exterior rearview mirror, rear enclosure, and interior panel are added with yellow embellishment, which looks more personalized.

  After understanding the basic information, what are the main highlights of this listing?

  The three distinguished models listed this time are all products created by Euler and users.The official said that the speed-up ability, climbing ability and quietness have all improved.For example, in terms of power, both the 401km and 501km versions are equipped with high-performance permanent magnet synchronous motors, with a maximum peak power of 135kW and a maximum torque of 232N·m, which is higher than the previous versions.

  In addition, there is also an improvement in quietness. As for how much improvement, we will verify it when we get the real car. Moreover, the honor model launched this time is basically the same as the previous top model in terms of configuration. In the case of an official limited time discount of 20,000, the price/performance ratio is good.

What are the competing products? What is the greatest advantage of Euler’s good cat?

  If you put the budget in the price range of 100,000-150,000 yuan, there are really many pure electric vehicles that you can choose now, including many popular models that have recently been listed. In the early days of 100,000 yuan, the more popular ones are BYD Dolphin, Baojun Yunduo and Volkswagen ID.3, and around 150,000 yuan, there is GAC AION Y. So what are the characteristics of these models?

  BYD DolphinAs a pure electric scooter, its overall performance is quite balanced. There is no obvious shortcoming in both internal and external design, spatial performance, or three electric systems. Coupled with the new energy aura of BYD brand, it has become the first choice of many people.

  Bao jun yun duoAs a latecomer, it has a certain advantage of being a latecomer. In the early 100,000 models, its space practicality and comfort are outstanding, and the sense of exquisiteness inside and outside has not been lost. You can experience the experience by paying attention to these two aspects.

  Dazhong ID.3With the increase of terminal concessions, the attention is also good. Its biggest advantage lies in the driving level. If you like the sense of control, this car is worthy of attention. Relatively speaking, it is relatively weak in the exquisite sense and configuration of the interior.

  If the price goes up,Guangzhou automobile AION YThe market performed well, with sales exceeding 17,000 vehicles in July. Its greatest advantage is the space performance, especially the back row space, which has leapfrog performance and is very practical for home use. However, the exquisite sense of the interior and exterior design of this car is not so prominent, and it is more suitable for those relatively pragmatic car users.

  The greatest feature of Euler’s good catIt is to take the refined route, especially the appearance and interior design are more characteristic in the same class, which is more attractive to female users. At the same time, in terms of configuration and space, it has reached the mainstream level of the same level. The honor model launched this time has a limited time discount of 20,000 yuan, and the cost performance is more prominent than before.

Decided to buy, which configuration is the most cost-effective?

  In fact, it is not difficult to choose the three models launched this time. Pursuing better dynamic performance and paying attention to more personalized internal and external design, we recommend the good cat GT Mulan version with limited time discount, and the pure battery life of 401km can also meet the needs of urban transportation.

  If you think that the honorable interior and exterior design of Good Cat meets your needs, you can choose a more entry-level model of 129,800 yuan, which is actually the top model before, so the configuration has been basically full, such as intelligent interactive system, on-board intelligent system, automatic air conditioning, front seat ventilation/heating/massage, etc., and at present you can enjoy the external discharge function of V2L for free, with outstanding cost performance, which is also a version recommended by individuals.

  Of course, if you think that the pure battery life of 401km is not enough, you can choose the version of 501km, and the difference is 16,000 yuan, mainly because the pure battery life is 100km more. If you are not particularly concerned about the pure battery life of 100km, I personally recommend the 401km version.

Editor’s comment:

  The three distinguished models launched this time (including two endurance versions of 401km and 501km) are actually versions created with users. In view of the pain points of users’ needs, these models have improved in speed-up, climbing ability and quietness. At the same time, in terms of configuration, compared with the previous top models, the official also gave a limited-time cash discount of 20,000 yuan, which made the cost performance relatively prominent. Compared with similar models, the Euler Good Cat model is more accurate in controlling the demand for female users. After all, the Euler brand has been deeply cultivating the female user market. Therefore, if you are paying attention to the household scooter of about 100,000 yuan recently, especially the female users, Euler Good Cat deserves attention.

Know more:

  The Euler brand was founded in 2018 and it has been five years since then. During these five years, Euler continued to deepen the female user market and formed a "cat family" product matrix. From cute little cats to retro ballet cats and coupe-style lightning cats, Euler meets the different preferences of female users with diversified layouts.

  At this conference, the Euler brand also completed the 400,000 th vehicle assembly line, which is of special significance. In addition to the domestic market, Euler is also laying out the global market. For example, Euler Good Cat has entered the European market and participated in the global competition. In April this year, Euler officially released the 1080 women’s safety architecture-warm technology brand strategy. Including three 360 degrees, that is, 360 basic safety+360 intelligent safety+360 health safety, and adhere to differentiated competition. Dong Yudong, general manager of brand technology of Euler Salon, said: "Euler will fully embrace the main channel of new energy technology competition and redefine the women’s track with technology."

Ten small shops in Qingdao that line up to the roadside may not eat if they have money.

????Although the store is small, it is very popular.

????Have you tried all these shops?

????Xizhen stinky tofu

????Every time I go, I have to queue up. It will always be the gathering place of authentic snacks in old Qingdao, still in its original position, still hot, and the taste is really great!

Ten small shops in Qingdao that line up to the roadside may not eat if they have money.

????Stinky tofu is fried very crisp, then soaked in his home-made vinegar juice, and then some pepper is added. Once bitten, the outside is crispy, and then the juice overflows. The tofu is soft inside, which is really delicious! Every time you finish eating, you have to drink all the soup to feel the most satisfied!

Ten small shops in Qingdao that line up to the roadside may not eat if they have money.

????Address:15a Wenshang Road, Shinan District (opposite to the former Fabao Supermarket)

????Xizhendian barbecue

????Next to the stinky tofu in Xizhen, it is also on Wenshang Road, next to the small door of Ma Lukou. It’s basically a semi-outdoor state. Only the barbecue equipment is in the house. I ordered kebabs and stood on the sidewalk. If there are not many lucky people, it’s better. If there are many people, I have to wait for a long time.

Ten small shops in Qingdao that line up to the roadside may not eat if they have money.

????Then you can eat in the yard. The so-called yard is the downstairs of people’s residential buildings. There is a shed where several people can sit, and some of them sit outside, all of which are particularly simple.

Ten small shops in Qingdao that line up to the roadside may not eat if they have money.

Ten small shops in Qingdao that line up to the roadside may not eat if they have money.

????Address:Wenshang Road, Shinan District (near Moore Market)

????Ignore

????On the barbecue street in Sifang Road, this is the old city, and the houses are relatively dilapidated. However, this family is still relatively hot, and there is a long queue. There is basically no room to sit in the house, so we have to pack it.

Ten small shops in Qingdao that line up to the roadside may not eat if they have money.

Ten small shops in Qingdao that line up to the roadside may not eat if they have money.

????Address:No.20 Huangdao Road, Shibei District

????Daoxiao Noodles, Qin Jin

????The famous Sifang Road barbecue gathering place originally had only one store, but now it has merged with two small shops across the street. The business is very hot, and everyone will go whenever they go.

Ten small shops in Qingdao that line up to the roadside may not eat if they have money.

????Quite authentic noodle restaurant in northern Shaanxi. We recommend Zhangzhongbao, Chinese hamburger, Daoxiao Noodles and oil sprinkled noodles. It’s not expensive and delicious. No wonder there are so many people.

Ten small shops in Qingdao that line up to the roadside may not eat if they have money.

????Address:Yizhou Road, Shinan District (near Yidujin)

????Where we eat skewers together in those years.

????Listening to the name of the store makes me feel very sentimental. The tableware also has logo, the walls are full of inspirational chicken soup, and the clerks are all wearing Mario’s clothes, which is very distinctive. Business is so hot that you have to queue up almost every time you go.

Ten small shops in Qingdao that line up to the roadside may not eat if they have money.

Ten small shops in Qingdao that line up to the roadside may not eat if they have money.

????Address:No.41 Dacheng Road, Taidong, Shibei District

????Siwei Beef Noodles (No.1 Middle School)

????This shop is also an old noodle restaurant with a long history. It is hidden in a residential building, and the door is not so conspicuous, but almost everyone has to queue up. It feels like this old shop is what an authentic foodie loves.

Ten small shops in Qingdao that line up to the roadside may not eat if they have money.

????The noodles are very strong, and the beef is really delicious. When it is cooked, it will melt very well in the mouth, and there is a lot of beef! It’s delicious with sour beans! It is also a good choice to come to this house if you want to eat beef noodles. It is worth a try.

Ten small shops in Qingdao that line up to the roadside may not eat if they have money.

????Address:No.1, nanyang road, Shinan District (Wenshui Road and nanyang road Intersection)

????Ririxing beef steak king

????I’m really afraid that they will quit the demolition here. This is a distinctive shop in the old city. The Fujian family has opened an old shop in Qingdao for more than 20 years. Every time they eat, it’s like going to the market. It’s just that there are many people, so they have to grab time to eat. Many people make the shop small!

Ten small shops in Qingdao that line up to the roadside may not eat if they have money.

????The price of a fly restaurant has gone up many times over the years, and some shops have imitated the practice here, but it has never been surpassed. The curry spicy steak tastes great, and the spicy taste and curry taste match just right. The steak soup mixed with rice is really excellent.

Ten small shops in Qingdao that line up to the roadside may not eat if they have money.

????Address:No.33 Yizhou Road, Shibei District

????Ruyi spicy chicken Jia (head store)

????There are many people in the shop, so the place where you can basically set the table is never wasted. His house has been open for many years, it belongs to an old shop, and the taste is still delicious!

Ten small shops in Qingdao that line up to the roadside may not eat if they have money.

????Spicy fried chicken rack, potato chips, and oil-sprinkled tofu skin are all necessary! Potato chips, soft and waxy, a little oily, with rice is also absolutely! His rice is delicious, too, with corn in it.

Ten small shops in Qingdao that line up to the roadside may not eat if they have money.

Ten small shops in Qingdao that line up to the roadside may not eat if they have money.

????Address:Qingtongxia Road, Shinan District (Guizhou Road)

????Pangtaitai Sichuan spicy sparerib chuan

????You can imagine how hot the people who line up extend from the door to the road, which is very suitable for friends to get together. A store with high cost performance.

Ten small shops in Qingdao that line up to the roadside may not eat if they have money.

????It has the flavor of Sichuan Shuan Chuan, and the ribs with honey sauce, palm treasure, pork tendon, squid head, squid slices and chicken wings are all delicious.

Ten small shops in Qingdao that line up to the roadside may not eat if they have money.

????Address:No.228-5 Liaoyuan Road, Shibei District (Shaoxing Road)

????Xinmingming ramen

????It is said that it is one of the best Lamian Noodles in Qingdao, and it is said to be open 24 hours a day. Old Lamian Noodles in Qingdao really has the taste of authentic Lamian Noodles when I was a child. The door of the shop is not big, and the business is very good. Every time I go there, there is a long queue, and stools are set up on the road outside and filled with people who eat noodles.

Ten small shops in Qingdao that line up to the roadside may not eat if they have money.

????Lamian Noodles is that kind of old flavor. The curry bowl in the soup has yellow oil on the side, and the noodles are strong. The soup is delicious, and the peppers are delicious and spicy! It’s also good to roast chicken heart in microwave oven!

Ten small shops in Qingdao that line up to the roadside may not eat if they have money.

????Address:No.39 Ninghua Road, Shibei District

????These 10 stores must eat!

????If you don’t eat, you’re not from Qingdao.

????Have you eaten all of them?

????I’m drooling from watching it!

Ten small shops in Qingdao that line up to the roadside may not eat if they have money.

Notice of Beijing Municipal Bureau of Commerce on Implementing Support Policies for Wholesale, Retail and Catering Enterprises in 2024

Jing Shang Xiao Zi [2024] No.11

Bureau of Commerce of all districts, Bureau of Commerce and Finance of Beijing Economic and Technological Development Zone, and relevant enterprises:

  In order to further promote the healthy development of wholesale and retail enterprises, benefit market players, help Beijing to build an international consumption center city, promote the high-quality development of the capital economy, and give financial support to qualified enterprises. The relevant matters are notified as follows:

  I. Scope of support

  Wholesale, retail and catering enterprises registered in Beijing with independent legal personality.

  Second, the support conditions and standards

  (1) Wholesale enterprises

  Reward wholesale enterprises whose annual main business income reaches 20 million yuan and above, and whose annual sales growth rate in 2024 is higher than the average growth rate of wholesale and retail sales in the city. In 2024, for every 100 million yuan increase in wholesale volume, the maximum reward is 40,000 yuan; If the growth rate of sales in the first quarter and the whole year is higher than the average growth rate of the whole city at the same time, it shall be supported according to the standard of 1.2 times; A single enterprise supports an upper limit of 10 million yuan.

  (2) Retail enterprises

  Reward retail enterprises whose annual main business income reaches 5 million yuan and above, and the annual retail sales growth rate in 2024 is higher than the average growth rate of the city’s total social zero. In 2024, the maximum reward for every 50 million yuan increase in retail sales is 200,000 yuan; If the growth rate of retail sales in the first quarter and the whole year is higher than the average growth rate of the whole city at the same time, it will be supported according to the standard of 1.2 times; A single enterprise supports an upper limit of 5 million yuan.

  (3) Catering enterprises

  Reward catering enterprises whose annual main business income reaches 2 million yuan and above, and the annual growth rate of catering business income in 2024 is higher than the average growth rate of catering business income in the city. In 2024, the highest reward for every 20 million yuan increase in catering business income is 80,000 yuan; If the growth rate of catering business income in the first quarter and the whole year is higher than the average growth rate of the whole city at the same time, it will be supported according to the standard of 1.2 times; A single enterprise supports an upper limit of 2 million yuan.

  (4) Newly established enterprises

  If it has been registered in Beijing for less than one year and meets the annual income conditions of its main business, it can be reported according to the monthly interval that meets the reporting requirements in that year.

  Third, the declaration process

  (1) Project declaration. From March 1 to April 30, 2025, eligible enterprises will submit the paper and electronic versions of the application materials to the local bureau of commerce and the bureau of commerce and finance of Beijing Economic and Technological Development Zone.

  (2) Project audit. The District Bureau of Commerce and the Bureau of Commerce and Finance of Beijing Economic and Technological Development Zone will conduct a preliminary examination of the application materials, and before May 30, 2025, the materials that have passed the preliminary examination will be summarized and submitted to the Municipal Bureau of Commerce for review.

  Fourth, the application materials

  The application materials shall be made in triplicate, bound into volumes in sequence, stamped with the official seal and riding seal of the unit (the full set of application materials shall be submitted together with the scanned electronic version). Project application materials will not be returned. The application materials are as follows:

  1. Application form;

  2 copies of the business license of the enterprise, the certificate of unified social credit code, the identity certificate of the legal representative and the bank account opening license;

  3. Relevant supporting materials such as the income scale and growth rate of the main business of the enterprise in 2024;

  4. Credit report (inquired and downloaded on the website of Credit China (Beijing)).

  V. Job Requirements

  (a) to ensure that the data is true, accurate and complete. The reporting enterprise shall not tamper with the relevant report information without authorization, and the reporting unit that forges or provides false materials shall not be supported, and shall be dealt with according to the Administrative Measures of Beijing Municipality on the List of Bad Credit Records in the Commercial Field (for Trial Implementation), and the support funds obtained shall be returned to the Municipal Bureau of Commerce.

  (2) Having a good credit record. It will not be supported in the following circumstances: failing to pay taxes in Beijing according to law; Included in the prohibited and restricted categories in the Catalogue of Prohibitions and Restrictions on New Industries in Beijing; Incorporated into the "blacklist" of joint punishment in the city; Being included in the list of bad credit records in Beijing’s commercial field and being punished by "not supporting" credit; The Municipal Bureau of Commerce and other departments to consider other non-support.

  (three) the reporting unit has not had any major or above production safety accidents in the past three years.

  (four) the same direction has been supported by the central financial funds or other municipal financial funds, and may not be repeated.

  (five) the preliminary examination units should actively organize the project declaration, do a good job of guidance and audit, strictly control, and do the relevant work in accordance with the prescribed procedures.

  (six) the project units that have received financial support should actively cooperate with the relevant supervision and inspection, auditing and other work. After receiving the financial funds, the project unit shall handle the accounts in accordance with the relevant provisions of the Notice of the Ministry of Finance on Printing and Amending the Accounting Standards for Business Enterprises No.16-Government Subsidies (Cai Shui [2017] No.15), unless otherwise stipulated by relevant laws and regulations.

  (seven) for interception, misappropriation, fraudulent financial funds and other illegal acts, in accordance with the "Regulations on Punishment of Financial Violations" (the State Council Decree No.427th, revised according to the State Council Decree No.588th in 2011) and other relevant provisions for punishment. If the case constitutes a crime, it shall be handed over to judicial organs for criminal responsibility.

  VI. Other matters

  This document shall be interpreted by the Municipal Bureau of Commerce and come into force as of the date of promulgation.

Maotai sells well near the Spring Festival: a bottle of more than 1850 is out of stock, which is comparable to grabbing a train ticket.

  As the Spring Festival approaches, the liquor market has entered the golden period of consumption, and Maotai Company has also increased its market input. However, according to a survey conducted by Beijing Youth Daily reporter, it is still hard to find a bottle of cheap Maotai. Not only is it normal for offline retailers to have high prices and out of stock, but it is even more difficult for scalpers to actually buy Maotai in several major online e-commerce platforms because they use ticketing software to sweep goods.

  The traditional festival is approaching, and the liquor market has entered the peak sales season. Although Maotai Group has continuously increased market supply, the most difficult liquor to buy this Spring Festival is probably the cheap flying Maotai. A survey by Beijing Youth Daily reporter found that Feitian Maotai was sold at a higher price in physical stores, with a maximum price of 1,850 yuan per bottle, which was out of stock. In online shopping malls, it is as difficult to grab a cheap Maotai as to grab a train ticket in Spring Festival travel rush, and consumers can’t compete with scalper’s snapping software by staying up all night. It is reported that Maotai Group tried its best to manage the Moutai market. On the one hand, the chairman repeatedly called dealers not to push up the market price of Moutai, and at the same time punished illegal dealers. On the other hand, it cracked down on scalpers. Last year, 487,000 scalper users were intercepted, but the governance effect was not satisfactory.

  offline

  No more than three bottles in the tobacco and liquor store.

  As the Spring Festival approaches, the liquor market has entered the golden period of consumption, and Maotai Company has increased its market input. However, in physical stores at the retail end, high prices and out-of-stock are still the norm. When the reporter of Beiqing Daily visited and investigated the retail end, it was found that some retailers were out of stock, and some stocks were very low, no more than five bottles, which could be counted in a slap.

  In a tobacco and alcohol specialty store located in the North Second Ring Road, the salesperson told the reporter of Beiqing Daily that Maotai is very tight now, with a price per day. It sold more than 1,400 and 1,600 some time ago, and now the price is 1,850 yuan, and "I can’t say what the price will be tomorrow." According to the salesman, Feitian Maotai in their store was out of stock for several months last year, and now it has just been replenished, but the inventory is no more than three bottles. "If you want to buy four or five bottles, just call one day in advance so that we can stock up and buy more without discount." In another tobacco and alcohol store in Wangfujing, the retail price of Feitian Maotai is 1,600 yuan. Manager Jiang, the boss, said frankly: "If I buy three bottles, I still have them in my hand. If I want to buy a box (a box of six bottles), there are really not so many."

  According to the survey, these tobacco and alcohol specialty stores sell at a higher price even if they have Maotai. At present, the official retail price of Feitian Maotai is 1499 yuan. According to the research report of CICC Securities, there is a serious shortage of Moutai in Shanghai, Jiangsu and Anhui, and high-end tobacco and alcohol retail terminals are generally only sold in scattered Maotai, with a retail price of 1,600 yuan/bottle.

  So where did the cheap Maotai go? On January 9th, at the "Symposium on Price Commitment of National Distributors of Maotai Liquor", some distributors complained that they had complied with the price but could not control the secondary reselling. "I sold 1,000 boxes of Moutai yesterday, and 60% of them went to tobacco hotels, small and medium-sized supermarkets and trading companies. Real consumers didn’t buy Maotai. " An Anhui dealer said.

  online

  "Software Party" and "Main Attack" Maotai official website

  In order to stabilize the market price, since last year, Kweichow Moutai has pushed the e-commerce platform to launch products and sold Feitian Maotai at a low price. Surprisingly, however, the online shopping mall and the snap-up link set up by the e-commerce platform let the scalpers see the opportunity to make a fortune. They used the ticketing software in their hands to expand their business scope from grabbing big hospital numbers and train tickets to grabbing Moutai wine orders. It is said that 10 accounts can grab 4 to 5 orders, so it is as difficult to grab Maotai online as it is to grab a train ticket in Spring Festival travel rush.

  However, careful attention has found that on the internet, there are always people who grab Maotai and immediately print the order, and then either don’t pay and wait for the order to expire; Either keep the original box receipt after receiving the goods and transfer it directly in the post bar. According to insiders, there are not many real consumers who buy Moutai online at present, because Maotai official website is also the platform of "software party" and "main attack", while the anti-scalper system on Maotai cloud merchants has limited ability, only controlling repeated addresses and swiping bills for many times, but not directly managing ID, so scalpers take the opportunity to fry wine.

  According to statistics, in 2017, Feitian Maotai shipped over 200,000 bottles on several major e-commerce platforms, which was equivalent to realizing 260 million yuan in cash. However, it was reported that most of these Moutai wines were returned to dealers or hoarded in the hands of speculators.

  respond

  Last year, more than 480,000 scalper users were intercepted.

  In response to the public concern about scalpers snapping up Moutai, relevant persons of Maotai E-commerce Company publicly responded that 200,000 bottles were put into Yunshang Double 12. At present, a total of 87,000 scalpers have been identified and intercepted. In 2017, 487,000 scalper users were directly intercepted, 73,000 scalper users were reserved, and 53,200 abnormal orders were closed.

  Regarding the specific governance measures taken for scalpers in the whole year of 2017, the person in charge said that Maotai E-commerce Company used its own abnormal user identification model including Ali WAF Ant Shield, Tencent Tianyu and Maotai E-commerce, covering machines, socialization, intentional forgery and other aspects, and strictly screened users before placing orders, and actively docked with relevant government departments to crack down on the phenomenon of scalper speculation.

  Yuan Renguo, chairman of Maotai Group, recently called on dealers not to push up the market price of Moutai and let consumers really drink it. He believes that the price fluctuation of Maotai market is small, and the increase is small. Keeping it in a reasonable range is beneficial to consumers and economic development. He stressed that since Moutai is used for "drinking" and "storing", it is necessary to treat the price rationally, and Moutai is not used for speculation.

  In addition to cracking down on scalpers, Maotai Group will also increase its market input. At the 2018 annual work meeting of Maotai Group held recently, Yuan Renguo said that based on the situation, Maotai proposed that the development goal in 2018 is to achieve tax-included income of 90 billion yuan; At the same time, the added value is about 78 billion yuan; The output and sales volume of liquor reached more than 120,000 tons; Pay taxes of 30 billion yuan; The income of companies other than joint-stock companies accounts for about 10% of the group. In addition, as the Spring Festival is approaching, Maotai plans to put in no less than 7,000 tons of Moutai and 6,000 tons of series wines to ensure the quantity before the Spring Festival.

  market

  Maotai’s market value approaches trillions.

  The tight situation of offline Moutai is transmitted to the capital market, which means that the stock price has soared, constantly hitting a record high. In 2018, Kweichow Moutai continued to rise for 8 trading days. On January 12th, Kweichow Moutai reported 788.42 yuan, up by 1.76%, with a total market value of 990.411 billion yuan, just one step away from one trillion yuan. A year ago, Maotai’s share price was 348.51 yuan, and its current market value has more than doubled.

  At the 2018 annual working meeting of Maotai held last week, Li Baofang, general manager of Maotai Group, said, "The capital market mainly allows investors to advance and cash their psychological expectations based on their own judgments. I hope that the stock of Maotai is the carrier for investors to share the value of Maotai, not the chip of short-term game; The stock price of Maotai is the true embodiment of the value of Maotai, not the rise caused by emotional follow-up or even speculative rashness. " He said that investors are welcome to treat and invest in Maotai with a rational and professional attitude and a pragmatic and long-term vision. According to media reports, Kweichow Moutai and LVMH Group are both constituent stocks of the global major luxury industry index. At present, Kweichow Moutai ranks first among the 18 constituent stocks, and LVMH Group ranks second.

  prospect

  The brokerage research report believes that Maotai will still raise prices in the future.

  According to the Capital Securities Research Report, at present, the price of a batch of Maotai Company is around 1,500 yuan. Before the price increase, the channel spread was close to that of 700 yuan. The price increase promoted the reasonable return of the channel profit, and after the price increase, the channel profit was still rich. They believe that the company may continue to raise prices in the future, and its performance in 2019-2020 is expected to continue to maintain steady growth.

  According to the analysis of industry organizations, Maotai’s performance growth in recent years is realized by product price increase and capacity increase. However, due to objective conditions, the capacity growth space of high-end liquor is limited. It is worth mentioning that Li Baofang, Party Secretary and General Manager of Maotai Group, recently revealed that the Moutai liquor expansion project is under construction, and it is estimated that after the expansion, the production capacity of 56,000 tons of Moutai liquor will be formed, but after this expansion and expansion, it will not be expanded in the short term. Personally, he believes that it will not expand production for at least 10 years. This means that if Kweichow Moutai wants to maintain high growth in the next few years, it may mainly rely on price increases to achieve it.

  Kweichow Moutai has always been favored by major brokers, and they have given higher expected target prices. However, the target price given by several brokers has been surpassed only a few trading days after the Kweichow Moutai research report was issued.

  For example, Xiao Chan and Ye Shuhuai of orient securities released a research report on December 28th, 2017, giving Kweichow Moutai a 15% premium based on the valuation of comparable companies, corresponding to a price-earnings ratio of 26 times in 2018 and a target price of 726.44 yuan. However, in the second trading day after the release of the research report, the share price of Kweichow Moutai reached 726.50 yuan, exceeding the above target price. In addition, on December 29, 2017, Northeast Securities also released a research report on the price adjustment of Moutai, and gave it a price-earnings ratio of 28 times in 2018, corresponding to a target price of 776.16 yuan. After just a few trading days, this target price was broken again. Last Friday, the closing price of Maotai was 788.42 yuan. Text/reporter Zhao Xinpei

Bojian, an American pharmaceutical company: It used to sell 700,000 yuan at a time, but now it’s a layoff stop loss.

In July 2020, the topic of "701,000 needles of rare diseases and drugs" rushed to Baidu hot search. This "high-priced medicine" is SMA
(Spinal muscular atrophy)
A revolutionary product in the field, Nosenac sodium. Behind the public opinion boom, its R&D manufacturer Bo Jian
(Biogen)
, and therefore is widely known in China.
SMA is the abbreviation of spinal muscular atrophy, which is called "the number one killer of genetic diseases in infants". Shortly after birth, children with SMA gradually lose all kinds of motor functions, including breathing and swallowing. If there is no specific medicine, most children will not live beyond 2 years old.
Nocicnatrium is the world’s first precise targeting drug for SMA. More than 1,600 children registered nationwide need lifelong medication, with 1.4 million in the first year and an average annual expenditure of 1.05 million thereafter. The people’s livelihood of rare diseases affects the heart of the Prime Minister, who pushes rare diseases into medical insurance to reduce the burden on the people.
At the national medical insurance negotiation at the end of 2021, Nosenac sodium was successfully included in the national medical insurance catalogue, with a dose of 33,000 yuan per needle.
After a few months, Bojian was once again concerned by the public, but it was full of negative keywords such as "layoffs", "selling shares" and "drugs were ruled by FDA".Bo Jian, the "leader", has important implications for innovative drug enterprises of rare diseases in China.

Text | Zhang Yuqi Wu Ni
Editor | Yin Lina
Cartography | Li Ziya

 March 28, 2022, Bojian
(BIIB.NASDAQ)
The treatment of amyotrophic lateral sclerosis is disclosed
(ALS)
The first-line results of the first-phase clinical trial of the antisense nucleic acid drug BIIB078 showed that the drug had no clinical benefit, so Bojian and Lonis decided to terminate their clinical trial and stop the loss in time.
Prior to this, in 2016, Bo Jian also suffered from spinal muscular atrophy
(hereinafter called "SMA")
Therapeutic drugs usher in a high-light moment. However, the research and development of new drugs is a "narrow escape", and Bo Jian is not spared. In the past few years, he has repeatedly suffered setbacks in the clinical stage.

According to media reports, a spokesman for Bojian said: "The company is implementing cost-cutting measures, and it is expected to save 500 million US dollars every year through layoffs."

The failure rate of research and development of Alzheimer’s disease is as high as 99.6%, which can be described as the defeat of Qian Fan. Since the 21st century, more than 320 clinical studies of global innovative pharmaceutical companies have failed. As a head biotechnology company in the field of neurology, Bojian is experiencing its "life and death field". Maybe the dust will settle before April 11th. Is Aduhelm still hopeful to be the next Nocicna sodium?

01


 
Ambition is hard to pay.

What can the Nobel Prize winners in chemistry, medicine and hepatitis B vaccine developers do together?
 
—— Established Bojian Company.
 Bojian
(Biogen)
Born in 1978, focusing on the field of neuroscience. Its founder team can be described as a luxury lineup. In 1980, Dr. Walter Gilbert, one of its founders, won the Nobel Prize in Chemistry. In 1993, another founder, Dr. Phillip Sharp, won the Nobel Prize in Physiology or Medicine; Dr Kenneth Murray was also knighted for developing hepatitis B vaccine.
Strong innovative genes, coupled with more than 40 years of precipitation and development, make Bojian gradually become a brother in the field of nervous system diseases, and in multiple sclerosis.
(MS)
Field and spinal muscular atrophy
(SMA)
Leading the way in the field.
In 2013, fumaric acid II developed by Bojian
(Tecfidera)
Approved by FDA, it has become one of the most widely used oral drugs in the field of MS treatment in the world. In 2019, Tecfidera’s sales reached a peak of 4.433 billion US dollars. In the same year, an upgraded version of dimethyl fumarate, deloximet fumarate.
(Vumerity)
Successful relay, approved by FDA, has a place in the market with better gastrointestinal tolerance and safety.
In 2016, Bojian developed the world’s first therapeutic drug for SMA-Nocicnatrium.
(Spinraza)
It has brought a major breakthrough to the field of rare diseases. With the first-Mover advantage, by the end of 2021, Nocicnatrium has brought nearly $9 billion in sales to Bojian.
Noxinasen sodium and dimethyl fumarate
(deloximet fumarate)
Become two carriages, pulling Bo Jian to run faster and faster.
However, the good times did not last long. In 2020, huge hidden dangers surfaced.
 
The first is the patent of dimethyl fumarate.
Bojian once carried out a series of patent layouts for dimethyl fumarate, and strived to monopolize the market until 2028.
But this is just Bo Jian’s wishful thinking. In February 2019, Mylan initiated a patent challenge to Bojian for dimethyl fumarate, and won the case, ending the exclusive period of dimethyl fumarate market ahead of schedule.
Subsequently, generic drugs flocked.
In China, there are 8 enterprises approved by CFDA, including Jiangsu Haosen, Jinan Bainuo and Hangzhou Heze. Under the impact of generic drugs, the performance of dimethyl fumarate in 2020 was $3.905 billion, down 12% year-on-year; In 2021, this figure dropped to $2.362 billion, a further drop of 39.5%.
The field of SMA is also not very optimistic. Although the patent of Nocina sodium will expire in 2023, the competing products have already approached. Zolgensma of Novartis and Evrysdi of Roche/Genentech were listed in 2019 and 2020, respectively, which encroached on the market of Nocicina sodium. The sales of Nosina sodium decreased from $2 billion in 2020 to $1.9 billion in 2021, while the sales revenue of Zolgensma in 2021 reached $1.351 billion, up 47% year-on-year.
Secondly, the research and development is "green and yellow." In order to maintain its advantages in SMA and MS, Bojian has never stopped innovating.
Unfortunately, it failed to make a breakthrough as expected.
In August, 2021, the research and development of multiple sclerosis drug opicinumab stopped in Phase II clinical trial, because the drug did not reach the primary and secondary endpoints in Phase II AFFINITY research. In January, 2022, Bojian introduced a global exclusive license of BiIB 115/Ion 306, a drug for SMA, from Ionis Pharmaceuticals. However, there is still a long way to go before it goes on the market.
Until now, Bojian has not waited for the next growth point, whether in SMA and MS fields or in new business fields.
The safety of Aduhelm, a highly anticipated drug for Alzheimer’s disease, has been controversial. According to Bojian’s 2021 financial report released on February 3, the sales of Aduhelm since its listing in June was only $3 million, far below expectations.
Gene therapy BIIB111 and BIIB112, non-opioid analgesic vixotrigine(BIIB074), antisense oligonucleotide drug tofersen, amyotrophic lateral sclerosis.
(ALS)
The candidate drug BIIB078 has successively declared clinical failure.
02


 
be bogged down in crisis

Repeated failures in research and development have made Bojian, which is based on innovative drugs, in danger.
The most intuitive feeling is that the performance has dropped significantly. In 2020, Bojian’s revenue was at the bottom of 14 multinational pharmaceutical companies. In 2021, Bojian hit a new low, and its revenue continued to decline by 18.3% year-on-year. The share price also hit a record low, falling by more than 36% from its August 2021 high.
Open source failed, and Bojian began to consider throttling.
In December 2021, more than 100 employees were dismissed, including two-thirds of the commercialization team of Aduhelm, a drug for Alzheimer’s disease. According to media reports in early March, Bojian may continue to lay off as many as 1,000 employees in order to save as much as $750 million.
Sadly,Senior executives who left Bojian synchronously with this layoff plan include AlfredSandrock, chief R&D officer of Bojian, and AlphonseGaldes, a veteran of Bojian who is responsible for global manufacturing.
In February this year, Bojian took its stake in Samsung Bioepis Company for as much as $2.3 billion.
(49.9% of the shares)
Sold to Samsung Bio. After the acquisition is completed, the two companies will continue to implement the exclusive agreement signed before, including the current portfolio
(Inaxip, adalimumab, Infliximab)
Commercialization. In addition, Bojian also has the exclusive right to commercialize rezumab and the biological similar drugs under research.
Layoffs and the sale of shares, or helpless actions, have also started a downward spiral cycle.
 
Along the way, Bojian’s red and black are equally bright, both determined by the product. Drugs for neurological diseases have always been called the "death knell" in the field of medical research and development, and it is even more billowing in the field of Alzheimer’s disease, but it has little effect. More than 99% of the drugs end up in the dust, leaving behind "the best of the best".
As you can imagine, Bo Jian
(Biogen)
How difficult this road is.
In October last year, Bo Jian frankly announced amyotrophic lateral sclerosis.
(ASL)
Valor, the third phase trial of Tofersen, has entered the "end point", and the popular explanation is that this drug may eventually fail to develop. This is nothing new to the original drug.Failure is the accumulation of experience, and success is accidental victory.
Aduhelm of Bojian
(aducanumab, aducanumab)
That’s about it.
American Association of Pharmaceutical Research and Manufacturers
(PhRMA)
According to the report data of,From 1998 to 2017, 146 drugs for Alzheimer’s disease have entered the "end point" of clinical trials worldwide, and only 4 drugs have successfully entered the market. In other words, only one out of every 37 drugs can be "successful".


       However, the "success" of R&D is only the first step, and whether it can be introduced to the market still needs "going through five customs and cutting six generals".
On June 7, 2021, FDA announced that Aduhelm, a new drug for Bojian’s Alzheimer’s Harmo’s disease.
(aducanumab, aducanumab)
Approved for use. After the news came out, Bojian’s share price rose sharply. After all, the research and development of AD drugs is very difficult, and Aduhelm is the seventh AD drug approved by FDA in the past 30 years, and it is also the re-approval of drugs in this field after 7 years.


      Although Bojian’s Aduhelm has been "recognized" by FDA, there have been many controversies, such as quarrels at expert meetings in the field, disapproval in markets outside the field, sales cliff, and even by the American Medical Insurance and Medicaid Service Center.(CMS)Restrictions.
During the seven-hour consultation meeting, various expert groups in FDA argued endlessly that "the relationship between amyloid protein in the brain and the pathogenesis of Alzheimer’s disease is uncertain". Neuroscientists and biostatisticians believe that Bojian’s experimental data are not valid and complete.
On the one hand, the expert group thinks that the FDA is suspected of harboring Bo Jian, and even three experts of the FDA Advisory Committee have resigned one after another, pointing directly at the FDA. They think that although the FDA pointed out the loopholes in biometric data, it still approved Bojian’s research and development drug-—Aduhelm in neurological review.
On the other hand, the Alzheimer’s Disease Association, the American Neurology Association and the International Alzheimer’s Harmo Disease Association expressed their support for Bojian’s new AD drug, and finally the FDA approved it.
03


 
 
Go on and on

Bo Jian, who is experiencing the storm of layoffs and the cliff of revenue, looks very embarrassed, but in fact, this is the only way to develop new drugs.
Compared with Bojian, those biotech enterprises that make false clinical trials and "pseudo-innovation" are the real "bubbles" in the ups and downs of the industry.
Industry insiders pointed out that "the phenomenon of nonstandard and incomplete data in drug clinical trials is still serious". As early as 2015, some clues were explored in the "July 22 verification storm" of the former State Food and Drug Administration. Among the 1622 drug clinical trials, more than 80% of new drug applications were withdrawn by pharmaceutical companies or "rejected" by the former State Food and Drug Administration.
Even multinational pharmaceutical company Merck
(MRK.NYSE)
Bristol-Myers Squibb
(BMY.NYSE)
It has also been revoked by the FDA.
On July 2, 2021, a paper came into view.
National Medical Products Administration medicines evaluation examination and approval center
(CDE)
Issued the relevant technical requirements for pharmaceutical common problems at the pre-market application meeting of innovative chemicals.
(Draft for Comment)
"and" guiding principles for clinical research and development of anti-tumor drugs oriented by clinical value "
(Draft for Comment)
In this paper, a head-to-head clinical trial with the latest treatment scheme is put forward, especially for tumor drugs, and the commercialization differences of products are clarified.The industry calls it "combating pseudo-innovation". For a time, the road of innovative drug research and development seems to be narrowing.
Although the research and development of new drugs is a narrow escape, some people die young and some people are lucky, but we have to say that biological research and development is a "cause" that burns money now and in the future, depending on who can be strong in the end.
From 2016 to 2021, Bojian’s R&D investment increased steadily, reaching the peak in recent years in 2020, with R&D expenditure reaching $3.991 billion, accounting for 29.58%. However, in 2021, due to multiple factors such as the epidemic situation and the research and development of new AD drugs, the R&D investment declined, with an investment of $2.501 billion and a year-on-year decrease of 6.91%.
In this protracted "controversy", despite Aduhelm’s obstruction, Bojian never gave up. In mid-December, 2021, Bojian announced that it would carry out a clinical IV trial with its development partner Wei Cai, which is expected to be completed within four years after the start of the study. As part of the Phase IV trial, Bojian and Weicai plan to recruit 18% American patients from African-American and Latino populations. Bojian said that this move is also part of continuous efforts to increase the diversity of Aduhelm clinical trials.
At the same time, Bo Jian is still exploring in various fields of neuroscience. Bojian is used to treat amyotrophic lateral sclerosis.
(ALS)
The clinical trial of BIIB078, an antisense oligonucleotide drug under research, has been terminated. On the evening of March 30th, the FDA was holding a PCNSDAC meeting to discuss another new drug of ALS-AMX0035 of -Amylys. The FDA still questioned its effectiveness, and the result is still waiting.
For Bojian, the American Center for Medicare and Medicaid Services
(CMS)
The "final verdict" has not yet arrived.
(Time is before April 11th, 2022)
,It is unknown where Aduhelm can go. Can Bojian come out with the next SMA? Maybe it’s still on its way.
Bi Jingquan, former director of the State Food and Drug Administration, said,
The high risk of innovative drugs should correspond to high returns.
.
(Click on the hyperlink to read the original text)
Faced with the high risk of a narrow escape, most people give up, but in clinic and market, if more people need to join, they need high-return opportunities. If the risk is high and there is no corresponding return, then who is willing to contribute to this biomedical industry with high failure rate?
 
(The author is a researcher at Caijing)

Shanghai Highlander’s price cuts hit at the end of the year! The latest offer is 226,800, and the car is sufficient.

[car home Shanghai Preferential Promotion Channel] Recently, a preferential storm was launched in Shanghai, with the highest preferential margin reaching 23,000 yuan and the lowest starting price of 226,800 yuan. If you are looking for a cost-effective SUV, don’t miss this excellent opportunity to buy a car. Click the "Check Car Price" button in the quotation form to get a higher discount!

上海地区汉兰达年末降价来袭!最新报价22.68万,现车充足

Highlander’s front face design is full of power and modernity. It adopts an integrated air intake grille with chrome decoration to make the vehicle look more dynamic and luxurious. The overall style is stable and powerful, the body lines are smooth, and the front part adopts a unique family design, which highlights the personality and recognition of the vehicle.

上海地区汉兰达年末降价来袭!最新报价22.68万,现车充足

Highlander’s side lines are smooth and elegant, with a body size of 4965*1930*1750mm and a wheelbase of 2850 mm. The lines on the side of the car are simple and powerful, showing a steady and atmospheric style. The front and rear wheel tracks are 1655mm and 1660mm respectively, which ensures the stability and handling of the vehicle. Paired with 235/55 R20 tires, it complements the exquisite 20-inch rim, showing the luxury and dynamism of Highlander.

上海地区汉兰达年末降价来袭!最新报价22.68万,现车充足

Highlander’s interior style is simple and atmospheric, adopting modern design concepts. The steering wheel is made of leather, which supports manual adjustment up and down and back and forth, bringing a comfortable grip and meeting the driver’s personalized demand for driving position. The center console is equipped with a 12.3-inch LCD screen, which integrates multimedia system, navigation, telephone, air conditioning and voice recognition control system of sunroof, so that drivers can easily control various functions. The front seats are made of leather and imitation leather, and the main driver’s seat has various adjustment modes such as front and rear adjustment, backrest adjustment, height adjustment (4-way) and lumbar support (2-way), providing a more comfortable and personalized riding experience. The front seats also have a heating function to provide warmth for drivers in cold weather. The second row of seats supports front and rear adjustment and backrest adjustment, and the rear seats can be laid down in proportion, providing flexible storage space. The front and rear rows are equipped with USB and Type-C interfaces, which meet the needs of modern drivers for charging electronic devices.

上海地区汉兰达年末降价来袭!最新报价22.68万,现车充足

Highlander’s 2.0T 248 horsepower L4 engine has excellent power performance, with a maximum power of 182kW and a maximum torque of 380 N m. With the 8-speed automatic manual transmission, it provides drivers with a strong and smooth driving experience.

Car home car owners’ evaluation of Highlander is quite pertinent: "After driving for a while, I really feel a lot. The hybrid power system with 2.5L engine and motor is quite good. At the beginning, it is driven by pure electricity, which is very quiet. After the speed comes up, the engine intervenes, the power can keep up, the acceleration response is fast, and you are confident of overtaking at high speed. Moreover, the fuel consumption per 100 kilometers can be controlled below 6L, which is economical and practical. I am very satisfied with the texture of the chassis. I was originally worried that the SUV’s body would sway when it was high. As a result, the chassis was compact and flexible when driving, and the shock absorption was soft. The suspension was not stiff when passing through the speed bump and the joint of the road, and the body swayed little. It can also properly convey the road feeling and drive with confidence. The driving experience is also great, the steering is light and flexible, the steering wheel and the body are in good synchronization, there is no delay, and my wife can easily drive. However, the car is not finished, and Highlander also has some minor shortcomings, such as the obvious vibration and sound when the engine is started with insufficient battery power. But overall, I think it is still very worth buying. "

Is "end-to-end" the optimal solution for autonomous driving?

  Author: Yang Zhongyang

  Recently, "end-to-end" has been on fire in the car circle! Tesla’s benchmark demonstration effect based on the "end-to-end" FSDV12 (fully autonomous driving) scheme, and the rumors of joining China, have driven companies such as "Wei Xiaoli" and service providers such as Huawei and Horizon to turn around and add end-to-end autonomous driving technology.

  The so-called "end-to-end" actually comes from the concept of deep learning, and English is "end-to-end (E2e)", which means that through an AI model, the final result can be output as long as the original data is input. When it is applied to the field of automatic driving, it means that only one model is needed to convert the sensing information collected by sensors such as camera, millimeter-wave radar and laser radar into specific operating instructions such as the steering angle of the vehicle, the stepping depth of the accelerator pedal and the braking strength, so that the vehicle can realize automatic driving. In the words of He Xiaopeng, the founder of Xpeng Motors, it is "very silky" and more like "human drivers driving".

  Previously, most autonomous driving systems on the market were traditional modular, that is, a mix-and-match system with artificial and intelligent worlds: perception relied on neural networks, and planning and control used algorithms designed manually by humans. The advantage of this system is that the division of labor is clear, and it is convenient to check and solve the defects in modules. But the problem is that this modular automatic driving system performs well in relatively simple driving tasks, and its ceiling is obvious in the face of complex driving tasks. Even the so-called advanced intelligent driving function of the city, which is far ahead, still has a sense of machinery, and it will also stop when it merges into the expressway and passes through a large intersection.

  Considering that the core challenge of autonomous driving is to solve endless edge scenes, the cost and time of solving the infinite long tail problem with limited manpower are incalculable, and data and modeling have become an inevitable trend. However, end-to-end, it is also a difficult technical job that needs careful polishing by the master.

  On the one hand, end-to-end needs massive high-quality data "feeding" training. Unlike the big language model, which can crawl a large amount of text data on the Internet for training, the cost and difficulty of obtaining video data for end-to-end intelligent driving are extremely high. Take Tesla as an example. At present, its FSD has accumulated more than 20 million human driving video clips, and the data collection cost of this scale only needs 5 billion to 8 billion yuan.

  On the other hand, end-to-end needs the support of powerful computing power. Automatic driving involves technologies and solutions such as lidar, image perception and V2X vehicle-road coordination. Powerful computing power is not only conducive to real-time processing of massive data, reducing data transmission delay, but also better supporting the whole scene for smart cities, smart transportation, high-level autonomous driving and so on. However, the computing power growth of domestic enterprises such as Huawei BU, Baidu Jiyue, Weilai, Ideality, Geely, Great Wall, Tucki, etc. are currently facing major bottlenecks.

  The problem is that the constraints of computing power and data will significantly affect the development of the algorithm. Although UniAD, an end-to-end autopilot model put forward by domestic academic circles, won the Best Paper Award of CPVR in 2023, which provides a reference direction for domestic enterprises, but UniAD developed under the open-loop verification system and small sample data still needs some engineering transformation and large-scale data training.

  In addition, the upper and lower limits of the autopilot system will be enlarged end to end. Because the end-to-end construction is a neural network black box, in the process of obtaining a higher upper limit, some of the interpretability of the traditional module scheme is transferred. How to retain the interpretability in the autopilot system and characterize the rules that should not be overstepped, such as don’t run a red light, into the neural network to ensure the end-to-end application and evolution safely, will also be an important topic for regulatory engineers.

  There are two routes to climb Mount Everest: one is the northern slope of Tibet, China, and the other is the southern slope of Nepal. Whether you choose to climb from the south slope or the north slope, you will eventually reach the same peak. This is similar to the current development path of autonomous driving. Although it is still difficult to determine that end-to-end is the optimal solution or final solution of autonomous driving, this does not hinder the innovation and exploration of enterprises. After all, end-to-end can handle extreme cases better than traditional modular methods, and it represents a more efficient way to reduce the dependence on manual coding. Based on this path, perhaps autonomous driving can lead to a higher stage. (Yang Zhongyang)

[Editor in charge:
Jin lingbing
]